IGF1-LR3

Sequence / Chemical Identity

Peptide Length: 83 amino acids
Structural Class: Recombinant long-acting analog of insulin-like growth factor 1 (IGF-1)
Modification:

• Arg substitution at position 3 (Glu→Arg)
• 13–amino acid N-terminal extension (MFPAMPLLSLFVN)

Molecular Data

Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ (commonly reported theoretical composition; may vary slightly by source)
Molecular Weight: ~9,100–9,200 g/mol (typically ~9,119 g/mol)
CAS Number: 946870-92-4 (used in some research catalogs; not universally standardized)

Receptor / Pathway Targets

Primary Research Targets: IGF-1 receptor (IGF1R)
Investigated Pathways:

• PI3K/Akt signaling pathway
• MAPK/ERK pathway
• Cellular growth, proliferation, and survival signaling
• Reduced binding affinity to IGF-binding proteins (IGFBPs), increasing bioavailability in experimental models

Purity Standard

≥95–98% (HPLC)

Appearance

White lyophilized powder

Storage

Store at −20°C
Protect from light and moisture
Reconstituted solutions should be stored frozen and used within a limited timeframe to maintain stability

Regulatory Status

For laboratory research use only
Not approved for human or veterinary use